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Description for Protein NME4

non-metastatic cells 4, protein expressed in
3 total interacting proteins; 2 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
The nucleoside diphosphate (NDP) kinases (EC 2.7.4.6) are ubiquitous enzymes that catalyze transfer of gamma-phosphates, via a phosphohistidine intermediate, between nucleoside and dioxynucleoside tri- and diphosphates. The enzymes are products of the nm23 gene family, which includes NME4 (Milon et al., 1997 [PubMed 9099850]).[supplied by OMIM] (PubMed Links)
Domains and Motifs:
  • NDK: Flavin reductase like domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.7.4.6
    KEGG - Orthology:
    K00940
    KEGG - Pathway(s):
    hsa00230; hsa00240; hsa01100
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Nonmetastatic protein 23, homolog 4; NM23H4; Metastasis inhibition factor NM23H4; NDP kinase mitochondrial; NDK; nm23 H4; Nucleoside diphosphate kinase mitochondrial
    Approved Symbol:
    NME4
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 1
    Human (de-) phosphorylation sites: 1; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 03489 Entrez Gene ID: 4833 OMIM ID: 601818 Swissprot Accession: O00746;