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Description for Protein NME2

non-metastatic cells 2, protein (NM23B) expressed in
33 total interacting proteins; 22 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 2/0)
(platelet: 1; secretome: 3)
Summary:
Nucleoside diphosphate kinase (NDK) exists as a hexamer composed of 'A' (encoded by NME1) and 'B' (encoded by this gene) isoforms. Multiple alternatively spliced transcript variants have been found for this gene. Read-through transcription from the neighboring upstream gene (NME1) generates naturally-occurring transcripts (NME1-NME2) that encode a fusion protein comprised of sequence sharing identity with each individual gene product. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • NDK: Flavin reductase like domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.7.4.6
    KEGG - Orthology:
    K00940
    KEGG - Pathway(s):
    hsa00230; hsa00240; hsa01100
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Nonmetastatic cells 2, protein expressed in; Metastasis inhibition factor NM23B; NM23B; NDPKB; C-myc transcription factor; EC 2.7.4.6; Nm23-H2; C-myc purine-binding transcription factor PUF; PUF; Nonmetastatic protein 23 homolog 2; Metastasis inhibition factor NM23B homolog 2; NM23H2; Nonmetastatic protein 23B; NDKB; NDP kinase B; Tumor metastatic process associated protein
    Approved Symbol:
    NME2
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 8
    Human (de-) phosphorylation sites: 8; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 1
    Human phosphorylation targets: 1; Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 5 : 0
  • Isoform 4 : 0
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 01132 Entrez Gene ID: 4831 OMIM ID: 156491 Swissprot Accession: P22392; Q6FHN3;