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Description for Protein NME1

non-metastatic cells 1, protein (NM23A) expressed in
21 total interacting proteins; 12 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 7/0)
(membrane: 2; microparticles: 1; platelet: 8; secretome: 2)
Summary:
This gene (NME1) was identified because of its reduced mRNA transcript levels in highly metastatic cells. Nucleoside diphosphate kinase (NDK) exists as a hexamer composed of 'A' (encoded by this gene) and 'B' (encoded by NME2) isoforms. Mutations in this gene have been identified in aggressive neuroblastomas. Two transcript variants encoding different isoforms have been found for this gene. Co-transcription of this gene and the neighboring downstream gene (NME2) generates naturally-occurring transcripts (NME1-NME2), which encodes a fusion protein comprised of sequence sharing identity with each individual gene product. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • NDK: Flavin reductase like domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.7.4.6
    KEGG - Orthology:
    K00940
    KEGG - Pathway(s):
    hsa00230; hsa00240; hsa01100
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Nucleoside-diphosphate kinase 1 isoform a; Nucleoside-diphosphate kinase 1 isoform b; Metastasis inhibition factor NM23; NM23; Nonmetastatic protein 23; Nonmetastatic protein 23, homolog 1; NM23H1; NDP kinase A; NDKA; Tumor metastatic process associated protein; nm23-H1 NDPKA; EC 2.7.4.6; Granzyme A-activated DNase; GAAD; AWD
    Approved Symbol:
    NME1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 14
    Human (de-) phosphorylation sites: 14; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 2
    Human phosphorylation targets: 2; Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • 2',3'-Dehydro-2',3'-Deoxy-Thymidine 5'-Diphosphate(db);
  • 2',3'-Dehydro-2',3'-Deoxy-Thymidine 5'-Triphosphate(db);
  • 2'-Deoxyguanosine-5'-Diphosphate(db);
  • 2'-Deoxyguanosine-5'-Triphosphate(db);
  • 3'-Azido-3'-Deoxythymidine-5'-Diphosphate(db);
  • 3'-Deoxy 3'-Amino Adenosine-5'-Diphosphate(db);
  • Adenosine Phosphonoacetic Acid(db);
  • Adenosine-5'-Diphosphate(db);
  • Fudp(db);
  • Guanosine-3',5'-Monophosphate(db);
  • Guanosine-5'-Diphosphate(db);
  • Pyrophosphate 2-(db);
  • Selenocysteine(db);
  • Thymidine-5'- Diphosphate(db)

    Associated Genetic Diseases:

  • Neuroblastoma(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 01131 Entrez Gene ID: 4830 OMIM ID: 156490 Swissprot Accession: P15531;