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Description for Protein NGF

nerve growth factor (beta polypeptide)
8 total interacting proteins; 3 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene is a member of the NGF-beta family and encodes a secreted protein which homodimerizes and is incorporated into a larger complex. This protein has nerve growth stimulating activity and the complex is involved in the regulation of growth and the differentiation of sympathetic and certain sensory neurons. Mutations in this gene have been associated with hereditary sensory and autonomic neuropathy, type 5 (HSAN5), and dysregulation of this gene's expression is associated with allergic rhinitis. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K02582
    KEGG - Pathway(s):
    hsa04010; hsa04210; hsa04722
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    NGF; Beta-NGF; Nerve growth factor; Beta-nerve growth factor; Nerve growth factor, beta polypeptide
    Approved Symbol:
    NGF
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 1
    Human (de-) phosphorylation sites: 1; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Clenbuterol(db)

    Associated Genetic Diseases:

  • Neuropathy, hereditary sensory and autonomic, type V(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 08874 Entrez Gene ID: 4803 OMIM ID: 162030 Swissprot Accession: P01138;