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Description for Protein NFYA

nuclear transcription factor Y, alpha
28 total interacting proteins; 6 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
The protein encoded by this gene is one subunit of a trimeric complex, forming a highly conserved transcription factor that binds to CCAAT motifs in the promoter regions in a variety of genes. Subunit A associates with a tight dimer composed of the B and C subunits, resulting in a trimer that binds to DNA with high specificity and affinity. The sequence specific interactions of the complex are made by the A subunit, suggesting a role as the regulatory subunit. In addition, there is evidence of post-transcriptional regulation in this gene product, either by protein degradation or control of translation. Further regulation is represented by alternative splicing in the glutamine-rich activation domain, with clear tissue-specific preferences for the two isoforms. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
None Available
KEGG - Orthology:
K08064
KEGG - Pathway(s):
hsa04612
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
Transcription factor NF-Y, A subunit; Nuclear factor binding to Y box of HLA genes; HAP2 CCAAT binding protein; CAAT-box DNA binding protein subunit A; CCAAT-binding transcription factor subunit B; CBF-A; CBF-B; HAP2; NF-YA; Nuclear transcription factor Y, alpha isoform 2; Nuclear transcription factor Y, alpha isoform 1
Approved Symbol:
NFYA
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 6
Human (de-) phosphorylation sites: 6; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

None Available

Associated Genetic Diseases:

None Available
Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 01793 Entrez Gene ID: 4800 OMIM ID: 189903 Swissprot Accession: P23511;