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Description for Protein NFX1

nuclear transcription factor, X-box binding 1
7 total interacting proteins; 3 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/1)
(platelet: 1)
Summary:
MHC class II gene expression is controlled primarily at the transcriptional level by transcription factors that bind to the X and Y boxes, two highly conserved elements in the proximal promoter of MHC class II genes. The protein encoded by this gene is a transcriptional repressor capable of binding to the conserved X box motif of HLA-DRA and other MHC class II genes in vitro. The protein may play a role in regulating the duration of an inflammatory response by limiting the period in which class II MHC molecules are induced by IFN-gamma. Three alternative splice variants, each of which encodes a different isoform, have been identified. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • RING: Ring finger
  • R3H: Putative single-stranded nucleic acids-binding domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    6.3.2.-
    KEGG - Orthology:
    K12236
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    NFX2; MGC20369; Transcriptional repressor NFX1; Nuclear transcription factor, X-box binding 1 isoform 1; Nuclear transcription factor, X-box binding 1 isoform 2; Nuclear transcription factor, X-box binding 1 isoform 3; EC 6.3.2.; TAP
    Approved Symbol:
    NFX1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 12
    Human (de-) phosphorylation sites: 12; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 11936 Entrez Gene ID: 4799 OMIM ID: 603255 Swissprot Accession: A0JLR2; Q12986;