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Description for Protein NFKBIB

nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
29 total interacting proteins; 13 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
NFKB1 (MIM 164011) or NFKB2 (MIM 164012) is bound to REL (MIM 164910), RELA (MIM 164014), or RELB (MIM 604758) to form the NFKB complex. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA, MIM 164008, or NFKBIB), which inactivate NF-kappa-B by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, MIM 600664 or IKBKB, MIM 603258) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T; R is an A or G purine; and Y is a C or T pyrimidine).[supplied by OMIM] (PubMed Links)
Domains and Motifs:
  • ANK: ankyrin repeats
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K02581
    KEGG - Pathway(s):
    hsa04062; hsa04621; hsa04622; hsa04623; hsa04660; hsa04662; hsa04722; hsa04920; hsa05131; hsa05140
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Inhibitor of kappa light chain gene enhancer in B cells, beta; NF-kappa-BIB; IKBB; Thyroid hormone receptor interactor 9; TRIP9; NF-kappaB inhibitor beta; IKB beta; IkBb-2; I-kappa-B-beta; TR-interacting protein 9; Thyroid receptor-interacting protein 9; Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta isoform a; Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta isoform b
    Approved Symbol:
    NFKBIB
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 8
    Human (de-) phosphorylation sites: 8; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 07260 Entrez Gene ID: 4793 OMIM ID: 604495 Swissprot Accession: Q15653; Q96LS1;