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Description for Protein NFKBIA

nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
76 total interacting proteins; 41 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/1)
(undefined: 1)
Summary:
NFKB1 (MIM 164011) or NFKB2 (MIM 164012) is bound to REL (MIM 164910), RELA (MIM 164014), or RELB (MIM 604758) to form the NFKB complex. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA or NFKBIB, MIM 604495), which inactivate NF-kappa-B by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, MIM 600664, or IKBKB, MIM 603258) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T; R is an A or G purine; and Y is a C or T pyrimidine).[supplied by OMIM] (PubMed Links)
Domains and Motifs:
  • ANK: ankyrin repeats
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K04734
    KEGG - Pathway(s):
    hsa04062; hsa04210; hsa04620; hsa04621; hsa04622; hsa04623; hsa04660; hsa04662; hsa04722; hsa04920; hsa05120; hsa05131; hsa05140; hsa05142; hsa05200; hsa05215; hsa05220; hsa05222
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Nuclear factor of kappa light chain gene enhancer in B cells inhibitor alpha; Nuclear factor of kappa light chain gene enhancer in B cells inhibitor; NFKBI; Inhibitor of kappa light chain gene enhancer in B cells alpha; IKBA; Major histocompatibility complex enhancer binding protein MAD3; Nuclear factor kappa B inhibitor
    Approved Symbol:
    NFKBIA
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 10
    Human (de-) phosphorylation sites: 10; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

  • Ectodermal dysplasia, anhidrotic, with T-cell immunodeficiency, autosomal dominant(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 01235 Entrez Gene ID: 4792 OMIM ID: 164008 Swissprot Accession: P25963;