Summary:
NF-kappa-B has been detected in numerous cell types that express cytokines, chemokines, growth factors, cell adhesion molecules, and some acute phase proteins in health and in various disease states. NF-kappa-B is activated by a wide variety of stimuli, such as cytokines, oxidant-free radicals, inhaled particles, ultraviolet irradiation, and bacterial or viral products. Inappropriate activation of NF-kappa-B has been linked to inflammatory events associated with autoimmune arthritis, asthma, septic shock, lung fibrosis, glomerulonephritis, atherosclerosis, and AIDS. In contrast, complete and persistent inhibition of NF-kappa-B has been linked directly to apoptosis, inappropriate immune cell development, and delayed cell growth. NFKB1 (MIM 164011) and NFKB2 encode p105 and p100 proteins that are processed to produce the active p50 and p52 NF-kappa-B subunits, respectively. However, the p100 and p105 proteins serve regulatory functions and should not be considered exclusively as precursor forms. The most abundant activated form of NF-kappa-B is a heterodimer of the p50 or p52 subunit bound to the RELA subunit (MIM 164014). Other NF-kappa-B complexes, consisting of hetero- and homodimers of p50, p52, RELA, REL (MIM 164910), and RELB (MIM 604758), have also been detected. NF-kappa-B complexes are inhibited by I-kappa-B proteins, NFKBIA (MIM 164008) or NFKBIB (MIM 604495), which inactivate NF-kappa-B by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by the kinases IKBKA (CHUK; MIM 600664) or IKBKB (MIM 603258) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B complex. The activated NF-kappa-B complex translocates into the nucleus and binds DNA at kappa-B-binding motifs, such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T; R is an A or G purine; and Y is a C or T pyrimidine). For reviews, see Chen et al. (1999) [PubMed 9895331] and Baldwin (1996) [PubMed 8717528].[supplied by OMIM] (PubMed Links)
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| Domains and Motifs:
CC: Coiled Coil
IPT: ig-like, plexins, transcription factors
ANK: ankyrin repeats
DEATH: DEATH domain, found in proteins involved in cell death (apoptosis).
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Gene Ontology:
KEGG - Enzyme ID(s):
KEGG - Orthology:
K04469
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KEGG - Pathway(s):
hsa04010; hsa05200
(The yellow boxes represents platelet proteins) |
Nomenclature / Alternative Names:
Transcription factor NFKB2; NFKB, p52/p100 subunit; Nuclear factor of kappa light chain gene enhancer in B cells 2; Oncogene LYT 10; LYT10; Lymphocyte translocation chromosome 10; Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 isoform b; Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 isoform a
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Approved Symbol:
| (De-) Phosphorylations:
Phosphorylation Targets:
| Total phosphorylation targets: 0 |
| Human phosphorylation targets: 0; | Predicted platelet targets: 0 |
| Protein Characteristics:
|  Associated Drugs (DrugBank Accession):
Glucosamine(db)
Associated Genetic Diseases:
None Available
| Predicted Transmembrane Domains:
Isoform 3 : 0
Isoform 2 : 0
Isoform 1 : 0
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