Search

Search for a specific protein in the Platelet Interactome


(Example: vasp)

 

Advanced Search

Get detailed protein information focusing on various characteristics and extract interaction networks

 

Legend

 

About

Go Back

Description for Protein NFKB1

nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
93 total interacting proteins; 39 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/1)
(undefined: 1)
Summary:
This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • IPT: ig-like, plexins, transcription factors
  • ANK: ankyrin repeats
  • DEATH: DEATH domain, found in proteins involved in cell death (apoptosis).
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K02580
    KEGG - Pathway(s):
    hsa04010; hsa04062; hsa04210; hsa04620; hsa04621; hsa04622; hsa04623; hsa04660; hsa04662; hsa04722; hsa04920; hsa05120; hsa05131; hsa05140; hsa05142; hsa05200; hsa05212; hsa05215; hsa05220; hsa05221; hsa05222
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Transcription factor NFKB1; Nuclear factor of kappa light chain gene enhancer in B cells 1; NFKB p105; NFKB p50
    Approved Symbol:
    NFKB1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 17
    Human (de-) phosphorylation sites: 17; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Pranlukast(db);
  • Thalidomide(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 01238 Entrez Gene ID: 4790 OMIM ID: 164011 Swissprot Accession: P19838;