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Description for Protein ATP12A

ATPase, H+/K+ transporting, nongastric, alpha polypeptide
No Interacting Proteins
Icon Book Platelet Evidence (proteome studies/others : 1/0)
(membrane: 1)
Summary:
The protein encoded by this gene belongs to the family of P-type cation transport ATPases. This gene encodes a catalytic subunit of the ouabain-sensitive H+/K+ -ATPase that catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. It is also responsible for potassium absorption in various tissues. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    3.6.3.10
    KEGG - Orthology:
    K01544
    KEGG - Pathway(s):
    hsa00190
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    ATPase, Na+/K+ transporting, alpha polypeptide like 1; Sodium/potassium ATPase, alpha polypeptide like; Potassium transporting ATPase alpha chain 2; Non-gastric H+/K+ ATPase alpha subunit
    Approved Symbol:
    ATP12A
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 4
    Human (de-) phosphorylation sites: 4; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 1 : 8
    • Additional Identifiers:

    HPRD: 01667 Entrez Gene ID: 479 OMIM ID: 182360 Swissprot Accession: P54707;