Search

Search for a specific protein in the Platelet Interactome


(Example: vasp)

 

Advanced Search

Get detailed protein information focusing on various characteristics and extract interaction networks

 

Legend

 

About

Go Back

Description for Protein ATP1A3

ATPase, Na+/K+ transporting, alpha 3 polypeptide
1 total interacting proteins;
Icon Book Platelet Evidence (proteome studies/others : 3/0)
(membrane: 1; platelet: 3)
Summary:
The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 3 subunit. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • TM: Transmembrane domain
  • CC: Coiled Coil
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    3.6.3.9
    KEGG - Orthology:
    K01539
    KEGG - Pathway(s):
    hsa04260; hsa04960; hsa04964; hsa04970
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Sodium Potassium ATPase, alpha 3 polypeptide; ATPase, Na+/K+ transporting, alpha 3 polypeptide; Sodium/potassium transporting ATPase alpha 3 chain; Sodium pump 3; Na+/K+ ATPase 3
    Approved Symbol:
    ATP1A3
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 5
    Human (de-) phosphorylation sites: 5; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

  • Dystonia 12(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 8
    • Additional Identifiers:

    HPRD: 01666 Entrez Gene ID: 478 OMIM ID: 182350 Swissprot Accession: P13637; B3KNQ8;