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Description for Protein NFATC3

nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
4 total interacting proteins; 1 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
The product of this gene is a member of the nuclear factors of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation and an inducible nuclear component. Other members of this family participate to form this complex also. The product of this gene plays a role in the regulation of gene expression in T cells and immature thymocytes. Several transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • IPT: ig-like, plexins, transcription factors
  • NLS: Nuclear localization signal
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K04446
    KEGG - Pathway(s):
    hsa04310; hsa04360; hsa04370; hsa04650; hsa04660; hsa04662
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    NFATx; NF-ATc3; T cell transcription factor NFAT4; Cytoplasmic nuclear factor of activated T-cells 3; Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3; NFAT4; Nuclear factor of activated T-cells, cytoplasmic 3; Cytoplasmic nuclear factor of activated T-cells 3 isoform 3; Cytoplasmic nuclear factor of activated T-cells 3 isoform 4; Cytoplasmic nuclear factor of activated T-cells 3 isoform 2; Cytoplasmic nuclear factor of activated T-cells 3 isoform 1
    Approved Symbol:
    NFATC3
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 20
    Human (de-) phosphorylation sites: 20; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 4 : 0
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 04077 Entrez Gene ID: 4775 OMIM ID: 602698 Swissprot Accession: B5B2S2; Q12968; B5B2S0;