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Description for Protein NFATC2

nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
18 total interacting proteins; 7 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene is a member of the nuclear factor of activated T cells (NFAT) family. The product of this gene is a DNA-binding protein with a REL-homology region (RHR) and an NFAT-homology region (NHR). This protein is present in the cytosol and only translocates to the nucleus upon T cell receptor (TCR) stimulation, where it becomes a member of the nuclear factors of activated T cells transcription complex. This complex plays a central role in inducing gene transcription during the immune response. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • IPT: ig-like, plexins, transcription factors
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K04446
    KEGG - Pathway(s):
    hsa04010; hsa04310; hsa04360; hsa04370; hsa04650; hsa04660; hsa04662
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    NFATP; Nuclear Factor Of Activated T Cells, Cytoplasmic, Calcineurin dependent 2; Nuclear factor of activated T cells, cytoplasmic 2; T cell transcription factor NFAT1; NFAT pre existing subunit; Preexisting nuclear factor of activated T-cells 2 isoform B; Preexisting nuclear factor of activated T-cells 2 isoform C
    Approved Symbol:
    NFATC2
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 59
    Human (de-) phosphorylation sites: 59; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 02730 Entrez Gene ID: 4773 OMIM ID: 600490 Swissprot Accession: B5B2N9; B5B2N8; Q13469;