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Description for Protein NFATC1

nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
12 total interacting proteins; 8 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
The product of this gene is a component of the nuclear factor of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation, and an inducible nuclear component. Proteins belonging to this family of transcription factors play a central role in inducible gene transcription during immune response. The product of this gene is an inducible nuclear component. It functions as a major molecular target for the immunosuppressive drugs such as cyclosporin A. Five transcript variants encoding distinct isoforms have been identified for this gene. Different isoforms of this protein may regulate inducible expression of different cytokine genes. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • IPT: ig-like, plexins, transcription factors
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K04446
    KEGG - Pathway(s):
    hsa04310; hsa04360; hsa04370; hsa04650; hsa04660; hsa04662
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Nfat transcription complex, cytosolic; NFAT2; NFATc; NF-ATC; Nuclear factor of activated T-cells, cytosolic component 1; Nuclear factor of activated T-cells, cytosolic component 1 isoform C; Nuclear factor of activated T-cells, cytosolic component 1 isoform B; Nuclear factor of activated T-cells, cytosolic component 1 isoform E; Nuclear factor of activated T-cells, cytosolic component 1 isoform A; Nuclear factor of activated T-cells, cytosolic component 1 isoform D
    Approved Symbol:
    NFATC1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 14
    Human (de-) phosphorylation sites: 14; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 5 : 0
  • Isoform 4 : 0
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 02729 Entrez Gene ID: 4772 OMIM ID: 600489 Swissprot Accession: O95644; B5B2M9; B5B2M8;