Search

Search for a specific protein in the Platelet Interactome


(Example: vasp)

 

Advanced Search

Get detailed protein information focusing on various characteristics and extract interaction networks

 

Legend

 

About

Go Back

Description for Protein ATP1A2

ATPase, Na+/K+ transporting, alpha 2 polypeptide
1 total interacting proteins; 1 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 1/0)
(platelet: 5)
Summary:
The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 2 subunit. Mutations in this gene result in familial basilar or hemiplegic migraines, and in a rare syndrome known as alternating hemiplegia of childhood. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    3.6.3.9
    KEGG - Orthology:
    K01539
    KEGG - Pathway(s):
    hsa04260; hsa04960; hsa04964; hsa04970
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    ATPase Na+/K+ transporting alpha 2 polypeptide; Sodium potassium ATPase alpha 2 polypeptide; Na,K-ATPase alpha A(+) catalytic polypeptide; Na,K-ATPase alpha B polypeptide; Sodium/potassium transporting ATPase alpha2 chain; Sodium pump 2; Na+/K+ ATPase 2; KIAA0778; Migraine hemiplegic 2; MHP2; FHM2
    Approved Symbol:
    ATP1A2
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 5
    Human (de-) phosphorylation sites: 5; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

  • Alternating hemiplegia of childhood(Pd);
  • Migraine, familial hemiplegic, 2(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 8
    • Additional Identifiers:

    HPRD: 01665 Entrez Gene ID: 477 OMIM ID: 182340 Swissprot Accession: P50993;