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Description for Protein ATP1A1

ATPase, Na+/K+ transporting, alpha 1 polypeptide
14 total interacting proteins; 9 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 1/0)
(membrane: 1)
Summary:
The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 1 subunit. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    3.6.3.9
    KEGG - Orthology:
    K01539
    KEGG - Pathway(s):
    hsa04260; hsa04960; hsa04964; hsa04970
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Alpha 1 Na,K-ATPase; ATPase Na+/K+ transporting alpha 1 polypeptide; Sodium potassium ATPase alpha 1 polypeptide; Na,K-ATPase alpha A catatlytic polypeptide; Sodium/potassium transporting ATPase alpha 1 chain; Sodium pump 1; Na+/K+ ATPase 1; Na+/K+ -ATPase alpha 1 subunit isoform b proprotein; Na+/K+ -ATPase alpha 1 subunit isoform a proprotein
    Approved Symbol:
    ATP1A1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 14
    Human (de-) phosphorylation sites: 14; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Acetyldigitoxin(db);
  • Almitrine(db);
  • Aluminium(db);
  • Bepridil(db);
  • Bretylium(db);
  • Deslanoside(db);
  • Diazoxide(db);
  • Digitoxin(db);
  • Digoxin(db);
  • Ethacrynic acid(db);
  • Hydroflumethiazide(db);
  • Magnesium(db);
  • Ouabain(db);
  • Potassium(db);
  • Trichlormethiazide(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 4
    01662_1(10)
    • Additional Identifiers:

    HPRD: 01662 Entrez Gene ID: 476 OMIM ID: 182310 Swissprot Accession: B7Z3U6; P05023; B7Z2T5;