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Description for Protein NEK2

NIMA (never in mitosis gene a)-related kinase 2
9 total interacting proteins; 4 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 1/1)
(phosphoproteome: 1; undefined: 1)
Summary:
(PubMed Links)
Domains and Motifs:
  • CC: Coiled Coil
  • S_T_kinase: Serine/Threonine protein kinases, catalytic domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.7.11.1
    KEGG - Orthology:
    K08857
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    NIMA related kinase 2; NLK1; HsPK 21; Serine/Threonine-protein kinase Nek2; Nima-like protein kinase 1; NEK2A
    Approved Symbol:
    NEK2
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 13
    Human (de-) phosphorylation sites: 13; Platelet phosphorylation sites: 1
    Phosphorylation Targets:
    Total phosphorylation targets: 27
    Human phosphorylation targets: 4; Predicted platelet targets: 23
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • 5-[(Z)-(5-CHLORO-2-OXO-1,2-DIHYDRO-3H-INDOL-3-YLIDENE)METHYL]-N-(DIETHYLAMINO)ETHYL]-2,4-DIMETHYL-1H-PYRROLE-3-CARBOXAMIDE(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 04953 Entrez Gene ID: 4751 OMIM ID: 604043 Swissprot Accession: P51955;