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Description for Protein NEFM

neurofilament, medium polypeptide
5 total interacting proteins; 4 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and functionally maintain neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the medium neurofilament protein. This protein is commonly used as a biomarker of neuronal damage. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • CC: Coiled Coil
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K04573
    KEGG - Pathway(s):
    hsa05014
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Neurofilament protein, medium polypeptide; Neurofilament medium polypeptide; NEFM; NF-M; NFM
    Approved Symbol:
    NEFM
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 38
    Human (de-) phosphorylation sites: 38; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 01205 Entrez Gene ID: 4741 OMIM ID: 162250 Swissprot Accession: P07197; Q9UK51;