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Description for Protein NDUFB6

NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 6, 17kDa
1 total interacting proteins; 1 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 1/0)
(membrane: 1)
Summary:
The protein encoded by this gene is a subunit of the multisubunit NADH:ubiquinone oxidoreductase (complex I). Mammalian complex I is composed of 45 different subunits. It locates at the mitochondrial inner membrane. This protein has NADH dehydrogenase activity and oxidoreductase activity. It transfers electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Alternative splicing occurs at this locus and two transcript variants encoding distinct isoforms have been identified. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    1.6.5.3; 1.6.99.3
    KEGG - Orthology:
    K03962
    KEGG - Pathway(s):
    hsa00190; hsa01100; hsa05010; hsa05012; hsa05016
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 6, 17kDa isoform 1; CI; NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 6, 17kDa; NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 6, 17kDa isoform 2; NADH-ubiquinone oxidoreductase 1 beta subcomplex 6; Complex 1 mitochondrial respiratory chain B17 subunit; Complex I-B17; CI-B17; B17; EC 1.6.5.3
    Approved Symbol:
    NDUFB6
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 2
    Human (de-) phosphorylation sites: 2; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • NADH(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 1
  • Isoform 1 : 1
    • Additional Identifiers:

    HPRD: 04504 Entrez Gene ID: 4712 OMIM ID: 603322 Swissprot Accession: O95139; Q5VYT2;