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Description for Protein ATIC

5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
13 total interacting proteins; 4 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 4/0)
(microparticles: 1; platelet: 3; secretome: 1)
Summary:
This gene encodes a bifunctional protein that catalyzes the last two steps of the de novo purine biosynthetic pathway. The N-terminal domain has phosphoribosylaminoimidazolecarboxamide formyltransferase activity, and the C-terminal domain has IMP cyclohydrolase activity. A mutation in this gene results in AICA-ribosiduria. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
2.1.2.3; 3.5.4.10
KEGG - Orthology:
K00602
KEGG - Pathway(s):
hsa00230; hsa00670; hsa01100
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
5 aminoimidazole 4 carboxamide ribonucleotide formyltranferase/IMP cyclohydrolase; AICARFT; IMPCHASE; Bifunctional purine biosynthesis protein PURH; PURH
Approved Symbol:
ATIC
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 10
Human (de-) phosphorylation sites: 10; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

  • 2-[5-Hydroxy-3-Methyl-1-(2-Methyl-4-Sulfo-Phenyl)-1h-Pyrazol-4-Ylazo]-4-Sulfo-Benzoic Acid(db);
  • 5--Monophosphate-9-Beta-D-Ribofuranosyl Xanthine(db);
  • Aicar(db);
  • Beta-Dadf, Msa, Multisubstrate Adduct Inhibitor(db);
  • Guanosine-5'-Monophosphate(db);
  • Pemetrexed(db);
  • Tetrahydrofolic acid(db)

    Associated Genetic Diseases:

  • Aica-ribosiduria due to ATIC deficiency(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 03434 Entrez Gene ID: 471 OMIM ID: 601731 Swissprot Accession: P31939;