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Description for Protein ACLY

ATP citrate lyase
8 total interacting proteins; 6 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 4/1)
(membrane: 1; phosphoproteome: 1; platelet: 1; secretome: 2; undefined: 1)
Summary:
ATP citrate lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The enzyme is a tetramer (relative molecular weight approximately 440,000) of apparently identical subunits. It catalyzes the formation of acetyl-CoA and oxaloacetate from citrate and CoA with a concomitant hydrolysis of ATP to ADP and phosphate. The product, acetyl-CoA, serves several important biosynthetic pathways, including lipogenesis and cholesterogenesis. In nervous tissue, ATP citrate-lyase may be involved in the biosynthesis of acetylcholine. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
2.3.3.8
KEGG - Orthology:
K01648
KEGG - Pathway(s):
hsa00020; hsa01100
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
CLATP; ATPCLTT; ATPCL; ATP-citrate synthase; EC 2.3.3.8; Citrate cleavage enzyme; ATP citrate lyase isoform 2; ATP citrate lyase isoform 1
Approved Symbol:
ACLY
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 31
Human (de-) phosphorylation sites: 31; Platelet phosphorylation sites: 1
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

None Available

Associated Genetic Diseases:

None Available
Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 00155 Entrez Gene ID: 47 OMIM ID: 108728 Swissprot Accession: P53396;