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Description for Protein NCK1

NCK adaptor protein 1
71 total interacting proteins; 39 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 2/1)
(phosphoproteome: 1; platelet: 8; undefined: 1)
Summary:
The protein encoded by this gene is one of the signaling and transforming proteins containing Src homology 2 and 3 (SH2 and SH3) domains. It is located in the cytoplasm and is an adaptor protein involved in transducing signals from receptor tyrosine kinases to downstream signal recipients such as RAS. Alternatively spliced transcript variants encoding different isoforms have been found. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SH3: Src homology 3 domains
  • SH2: Src homology 2 domains
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K07365
    KEGG - Pathway(s):
    hsa04012; hsa04360; hsa04660; hsa05130
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    NCK; NCK alpha; NCK adaptor protein 1; Cytoplasmic protein NCK1; SH2/SH3 adaptor protein NCK alpha; NCK tyrosine kinase; MGC12668; Non catalytic region of tyrosine kinase
    Approved Symbol:
    NCK1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 14
    Human (de-) phosphorylation sites: 14; Platelet phosphorylation sites: 1
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 02740 Entrez Gene ID: 4690 OMIM ID: 600508 Swissprot Accession: P16333;