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Description for Protein NASP

nuclear autoantigenic sperm protein (histone-binding)
12 total interacting proteins; 4 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes a H1 histone binding protein that is involved in transporting histones into the nucleus of dividing cells. Multiple isoforms are encoded by transcript variants of this gene. The somatic form is expressed in all mitotic cells, is localized to the nucleus, and is coupled to the cell cycle. The testicular form is expressed in embryonic tissues, tumor cells, and the testis. In male germ cells, this protein is localized to the cytoplasm of primary spermatocytes, the nucleus of spermatids, and the periacrosomal region of mature spermatozoa. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • TPR: Tetratricopeptide repeats
  • CC: Coiled Coil
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K11291
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    Nuclear autoantigenic sperm protein isoform 1; Nuclear autoantigenic sperm protein isoform 2; Nuclear autoantigenic sperm protein isoform 3; N1/N2; Histone H1-binding protein; Nuclear autoantigenic sperm protein (histone-binding); FLB7527; MGC2297; PRO1999; FLJ31599; FLJ35510; MGC19722; MGC20372; DKFZp547F162
    Approved Symbol:
    NASP
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 67
    Human (de-) phosphorylation sites: 67; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 04423 Entrez Gene ID: 4678 OMIM ID: 603185 Swissprot Accession: P49321; Q5T626;