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Description for Protein NAGA

N-acetylgalactosaminidase, alpha-
1 total interacting proteins; 1 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
NAGA encodes the lysosomal enzyme alpha-N-acetylgalactosaminidase, which cleaves alpha-N-acetylgalactosaminyl moieties from glycoconjugates. Mutations in NAGA have been identified as the cause of Schindler disease types I and II (type II also known as Kanzaki disease). [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    3.2.1.49
    KEGG - Orthology:
    K01204
    KEGG - Pathway(s):
    hsa00603; hsa04142
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Alpha-GalNAc; GLAB; N-Acetyl Alpha-D-galactosidase; EC 3.2.1.49
    Approved Symbol:
    NAGA
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 2
    Human (de-) phosphorylation sites: 2; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Glycerol(db)

    Associated Genetic Diseases:

  • Kanzaki disease(Pd);
  • Schindler disease, type I(Pd);
  • Schindler disease, type III(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 00076 Entrez Gene ID: 4668 OMIM ID: 104170 Swissprot Accession: P17050;