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Description for Protein PPP1R12B

protein phosphatase 1, regulatory (inhibitor) subunit 12B
5 total interacting proteins; 4 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/1)
(platelet: 1)
Summary:
Summary: Myosin phosphatase is a protein complex comprised of three subunits: a catalytic subunit (PP1c-delta, protein phosphatase 1, catalytic subunit delta), a large regulatory subunit (MYPT, myosin phosphatase target) and small regulatory subunit (sm-M20). Two isoforms of MYPT have been isolated--MYPT1 and MYPT2, the first of which is widely expressed, and the second of which may be specific to heart, skeletal muscle, and brain. Each of the MYPT isoforms functions to bind PP1c-delta and increase phosphatase activity. This locus encodes both MYTP2 and M20. Alternatively spliced transcript variants encoding different isoforms have been identified. Related pseudogenes have been defined on the Y chromosome. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • ANK: ankyrin repeats
  • CC: Coiled Coil
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K12329
    KEGG - Pathway(s):
    hsa04270
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    MYPT2; Myosin phosphatase targeting subunit 2; Myosin phosphatase regulatory subunit; Myosin phosphatase target subunit 2; EC 3.1.3.53; Protein phosphatase 1 regulatory (inhibitor) subunit 12B isoform b; Protein phosphatase 1 regulatory (inhibitor) subunit 12B isoform a; Protein phosphatase 1 regulatory (inhibitor) subunit 12B isoform d; Protein phosphatase 1 regulatory (inhibitor) subunit 12B isoform c
    Approved Symbol:
    PPP1R12B
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 18
    Human (de-) phosphorylation sites: 18; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 4 : 0
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 04794 Entrez Gene ID: 4660 OMIM ID: 603768 Swissprot Accession: O60237; Q2TAI8; A6NM75;