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Description for Protein MYO9B

myosin IXB
5 total interacting proteins; 4 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 1/2)
(phosphoproteome: 1; platelet: 1; undefined: 1)
Summary:
This gene encodes a member of the myosin family of actin-based molecular motor heavy chain proteins. The protein has four IQ motifs located in the neck domain that bind calmodulin, which serves as a light chain. The protein complex has a single-headed structure and exhibits processive movement on actin filaments toward the minus-end. The protein also has rho-GTPase activity. Polymorphisms in this gene are associated with celiac disease and ulcerative colitis susceptibility. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • IQ: Short calmodulin-binding motif containing conserved Ile and Gln residues.
  • RA: Ras association (RalGDS/AF-6) domain
  • C1: Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
  • RHOGAP: GTPase-activator protein for Rho-like GTPases
  • CC: Coiled Coil
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K10360
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    MYR5
    Approved Symbol:
    MYO9B
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 36
    Human (de-) phosphorylation sites: 36; Platelet phosphorylation sites: 4
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

  • Celiac disease, susceptibility to, 4(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 03677 Entrez Gene ID: 4650 OMIM ID: 602129 Swissprot Accession: Q8WVD2; B0I1T6; Q4LE74;