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Description for Protein MYLK

myosin light chain kinase
18 total interacting proteins; 14 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 9/2)
(ATP binding: 1; membrane: 1; microparticles: 1; phosphoproteome: 1; platelet: 16; secretome: 7; undefined: 1)
Summary:
This gene, a muscle member of the immunoglobulin gene superfamily, encodes myosin light chain kinase which is a calcium/calmodulin dependent enzyme. This kinase phosphorylates myosin regulatory light chains to facilitate myosin interaction with actin filaments to produce contractile activity. This gene encodes both smooth muscle and nonmuscle isoforms. In addition, using a separate promoter in an intron in the 3' region, it encodes telokin, a small protein identical in sequence to the C-terminus of myosin light chain kinase, that is independently expressed in smooth muscle and functions to stabilize unphosphorylated myosin filaments. A pseudogene is located on the p arm of chromosome 3. Four transcript variants that produce four isoforms of the calcium/calmodulin dependent enzyme have been identified as well as two transcripts that produce two isoforms of telokin. Additional variants have been identified but lack full length transcripts. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • IGC2: Immunoglobulin C-2 Type
  • FN3: Fibronectin type 3 domain
  • S_T_kinase: Serine/Threonine protein kinases, catalytic domain
  • S_T_Y_Kinase: Protein kinase
  • unclassified specificity
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.7.11.18
    KEGG - Orthology:
    K00907
    KEGG - Pathway(s):
    hsa04020; hsa04270; hsa04510; hsa04810
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    MLCK; Myosin light chain kinase; Telokin; Kinase related protein; Myosin light polypeptide kinase; EC 2.7.1.117; MLCK108; MLCK210; FLJ12216; Myosin light chain kinase isoform 6; Myosin light chain kinase isoform 2; Myosin light chain kinase isoform 3B; Kinase related protein telokin isoform 8; Kinase related protein telokin isoform 7; KRP; Myosin light chain kinase isoform 3A; Myosin light chain kinase isoform 1
    Approved Symbol:
    MYLK
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 72
    Human (de-) phosphorylation sites: 72; Platelet phosphorylation sites: 38
    Phosphorylation Targets:
    Total phosphorylation targets: 2
    Human phosphorylation targets: 2; Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 9 : 0
  • Isoform 8 : 0
  • Isoform 7 : 0
  • Isoform 6 : 0
  • Isoform 5 : 0
  • Isoform 4 : 0
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 02952 Entrez Gene ID: 4638 OMIM ID: 600922 Swissprot Accession: Q15746; Q9UBY6; Q6P2N0;