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Description for Protein MYH7

myosin, heavy chain 7, cardiac muscle, beta
4 total interacting proteins;
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
Muscle myosin is a hexameric protein containing 2 heavy chain subunits, 2 alkali light chain subunits, and 2 regulatory light chain subunits. This gene encodes the beta (or slow) heavy chain subunit of cardiac myosin. It is expressed predominantly in normal human ventricle. It is also expressed in skeletal muscle tissues rich in slow-twitch type I muscle fibers. Changes in the relative abundance of this protein and the alpha (or fast) heavy subunit of cardiac myosin correlate with the contractile velocity of cardiac muscle. Its expression is also altered during thyroid hormone depletion and hemodynamic overloading. Mutations in this gene are associated with familial hypertrophic cardiomyopathy, myosin storage myopathy, dilated cardiomyopathy, and Laing early-onset distal myopathy. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • MYOSIN: Myosin. Large ATPases
  • IQ: Short calmodulin-binding motif containing conserved Ile and Gln residues.
  • CC: Coiled Coil
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K10352
    KEGG - Pathway(s):
    hsa04260; hsa04530; hsa05410; hsa05414; hsa05416
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Myosin cardiac heavy chain, beta; MYHCB
    Approved Symbol:
    MYH7
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 8
    Human (de-) phosphorylation sites: 8; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • 4-[4-(2,5-DIOXO-PYRROLIDIN-1-YL)-PHENYLAMINO]-4-HYDROXY-BUTYRIC ACID(db)

    Associated Genetic Diseases:

  • Cardiomyopathy, dilated, 1S(Pd);
  • Cardiomyopathy, familial hypertrophic, 1(Pd);
  • Cardiomyopathy, hypertrophic, midventricular, digenic(Pd);
  • Laing distal myopathy(Pd);
  • Myopathy, myosin storage(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 01175 Entrez Gene ID: 4625 OMIM ID: 160760 Swissprot Accession: P12883;