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Description for Protein MYH3

myosin, heavy chain 3, skeletal muscle, embryonic
No Interacting Proteins
Icon Book Platelet Evidence (proteome studies/others : 1/0)
(platelet: 1)
Summary:
Myosin is a major contractile protein which converts chemical energy into mechanical energy through the hydrolysis of ATP. Myosin is a hexameric protein composed of a pair of myosin heavy chains (MYH) and two pairs of nonidentical light chains. This gene is a member of the MYH family and encodes a protein with an IQ domain and a myosin head-like domain. Mutations in this gene have been associated with two congenital contracture (arthrogryposis) syndromes, Freeman-Sheldon syndrome and Sheldon-Hall syndrome. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • MYOSIN: Myosin. Large ATPases
  • IQ: Short calmodulin-binding motif containing conserved Ile and Gln residues.
  • CC: Coiled Coil
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K10352
    KEGG - Pathway(s):
    hsa04530; hsa05416
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    SMHCE; Myosin heavy chain, fast skeletal muscle, embryonic; MYHC-EMB; MYHSE1; Myosin, skeletal, heavy chain, embryonic 1; Myosin, heavy chain 3, skeletal muscle, embryonic
    Approved Symbol:
    MYH3
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 5
    Human (de-) phosphorylation sites: 5; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

  • Arthrogryposis, distal, type 2A(Pd);
  • Arthrogryposis, distal, type 2B(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 01172 Entrez Gene ID: 4621 OMIM ID: 160720 Swissprot Accession: P11055;