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Description for Protein MYCN

v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)
7 total interacting proteins; 4 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene is a member of the MYC family and encodes a protein with a basic helix-loop-helix (bHLH) domain. This protein is located in the nucleus and must dimerize with another bHLH protein in order to bind DNA. Amplification of this gene is associated with a variety of tumors, most notably neuroblastomas. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • HLH: helix loop helix domain
  • CC: Coiled Coil
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K09109
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    N-myc proto-oncogene protein; NMYC; V-myc avian myelocytomatosis virus related oncogene neuroblastoma derived; Oncogene NMYC; NMYC oncogene; Avian myelocytomatosis viral related oncogene neuroblastoma derived; Neuroblastoma MYC oncogene
    Approved Symbol:
    MYCN
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 9
    Human (de-) phosphorylation sites: 9; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

  • Feingold syndrome(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 01278 Entrez Gene ID: 4613 OMIM ID: 164840 Swissprot Accession: P04198; Q53XS5;