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Description for Protein MTR

5-methyltetrahydrofolate-homocysteine methyltransferase
2 total interacting proteins; 2 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 1/0)
(platelet: 3)
Summary:
MTR encodes the enzyme 5-methyltetrahydrofolate-homocysteine methyltransferase. This enzyme, also known as cobalamin-dependent methionine synthase, catalyzes the final step in methionine biosynthesis. Mutations in MTR have been identified as the underlying cause of methylcobalamin deficiency complementation group G. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
2.1.1.13
KEGG - Orthology:
K00548
KEGG - Pathway(s):
hsa00270; hsa00670; hsa01100
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
Tetrahydropteroylglutamate methyltransferase; Methionine synthase; Methionine synthase, vitamin-B12 dependent; MS
Approved Symbol:
MTR
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 1
Human (de-) phosphorylation sites: 1; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

  • Cyanocobalamin(db);
  • Hydroxocobalamin(db);
  • L-Methionine(db);
  • Tetrahydrofolic acid(db)

    Associated Genetic Diseases:

  • Methylcobalamin deficiency, CBLG type(Pd);
  • Neural tube defects, folate-sensitive, susceptibility to(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 01136 Entrez Gene ID: 4548 OMIM ID: 156570 Swissprot Accession: Q99707;