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Description for Protein MTAP

methylthioadenosine phosphorylase
1 total interacting proteins;
Icon Book Platelet Evidence (proteome studies/others : 2/0)
(platelet: 1; secretome: 2)
Summary:
This gene encodes an enzyme that plays a major role in polyamine metabolism and is important for the salvage of both adenine and methionine. The encoded enzyme is deficient in many cancers because this gene and the tumor suppressor p16 gene are co-deleted. Multiple alternatively spliced transcript variants have been described for this gene, but their full-length natures remain unknown. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
2.4.2.28
KEGG - Orthology:
K00772
KEGG - Pathway(s):
hsa00270; hsa01100
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
5`-methylthioadenosine phosphorylase; MTA phosphorylase; MTAPase; MeSAdo phosphorylase; MSAP
Approved Symbol:
MTAP
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 6
Human (de-) phosphorylation sites: 6; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

  • (1s)-1-(9-Deazaadenin-9-Yl)-1,4,5-Trideoxy-1,4-Imino-5-Methylthio-D-Ribitol(db);
  • 5'-Deoxy-5'-(Methylthio)-Tubercidin(db);
  • 5'-Deoxy-5'-Methylthioadenosine(db);
  • Adenine(db);
  • Formycin(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 01134 Entrez Gene ID: 4507 OMIM ID: 156540 Swissprot Accession: Q13126;