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Description for Protein MSH5

mutS homolog 5 (E. coli)
1 total interacting proteins;
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes a member of the mutS family of proteins that are involved in DNA mismatch repair and meiotic recombination. This protein is similar to a Saccharomyces cerevisiae protein that participates in segregation fidelity and crossing-over events during meiosis. This protein plays a role in promoting ionizing radiation-induced apoptosis. This protein forms heterooligomers with another member of this family, mutS homolog 4. Polymorphisms in this gene have been linked to various human diseases, including IgA deficiency, common variable immunodeficiency, and premature ovarian failure. Alternative splicing results multiple transcript variants. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • MUTSd: DNA-binding domain of DNA mismatch repair MUTS family
  • MUTSac: ATPase domain of DNA mismatch repair MUTS family
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K08741
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    NG23; MutSH5; G7, MutS; MutS homolog 5 isoform c; MutS homolog 5 isoform a; MutS homolog 5 isoform b
    Approved Symbol:
    MSH5
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 4 : 0
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 04544 Entrez Gene ID: 4439 OMIM ID: 603382 Swissprot Accession: O43196;