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Description for Protein MSH3

mutS homolog 3 (E. coli)
8 total interacting proteins; 1 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
The protein encoded by this gene forms a heterodimer with MSH2 to form MutS beta, part of the post-replicative DNA mismatch repair system. MutS beta initiates mismatch repair by binding to a mismatch and then forming a complex with MutL alpha heterodimer. Defects in this gene are a cause of susceptibility to endometrial cancer. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • MUTSd: DNA-binding domain of DNA mismatch repair MUTS family
  • MUTSac: ATPase domain of DNA mismatch repair MUTS family
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K08736
    KEGG - Pathway(s):
    hsa03430; hsa05200; hsa05210
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    MutS; DNA mismatch repair protein Msh3; Divergent upstream protein; DUP; Mismatch repair protein 1; MRP1; DUG; DUC1
    Approved Symbol:
    MSH3
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 6
    Human (de-) phosphorylation sites: 6; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

  • Endometrial cancer(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 02931 Entrez Gene ID: 4437 OMIM ID: 600887 Swissprot Accession: P20585;