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Description for Protein ABCC1

ATP-binding cassette, sub-family C (CFTR/MRP), member 1
No Interacting Proteins
Icon Book Platelet Evidence (proteome studies/others : 2/0)
(membrane: 1; platelet: 6)
Summary:
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra-and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a multispecific organic anion transporter, with oxidized glutatione, cysteinyl leukotrienes, and activated aflatoxin B1 as substrates. This protein also transports glucuronides and sulfate conjugates of steroid hormones and bile salts. Alternative splicing by exon deletion results in several splice variants but maintains the original open reading frame in all forms. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • TM: Transmembrane domain
  • AAA: ATPases associated with a variety of cellular activities
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K05665
    KEGG - Pathway(s):
    hsa02010
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    ATP binding cassette subfamily C member 1 isoform 6; ATP binding cassette subfamily C member 1 isoform 7; ATP binding cassette subfamily C member 1 isoform 3; ATP binding cassette subfamily C member 1 isoform 2; ATP binding cassette subfamily C member 1 isoform 5; ATP binding cassette subfamily C member 1 isoform 4; ATP binding cassette subfamily C member 1 isoform 1; Multidrug resistance associated protein 1; MRP1; ABC29; GS-X; ATP binding cassette subfamily C, CFTR/MRP member 1; MRP
    Approved Symbol:
    ABCC1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 64
    Human (de-) phosphorylation sites: 64; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Sulfinpyrazone(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
    01153_7(16)
    01153_6(16)
    01153_5(16)
    01153_4(16)
    01153_3(15)
    01153_2(15)
    01153_1(16)
    Additional Identifiers:

    HPRD: 01153 Entrez Gene ID: 4363 OMIM ID: 158343 Swissprot Accession: P33527; C9JPJ4;