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Description for Protein MRE11A

MRE11 meiotic recombination 11 homolog A (S. cerevisiae)
26 total interacting proteins; 7 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes a nuclear protein involved in homologous recombination, telomere length maintenance, and DNA double-strand break repair. By itself, the protein has 3' to 5' exonuclease activity and endonuclease activity. The protein forms a complex with the RAD50 homolog; this complex is required for nonhomologous joining of DNA ends and possesses increased single-stranded DNA endonuclease and 3' to 5' exonuclease activities. In conjunction with a DNA ligase, this protein promotes the joining of noncomplementary ends in vitro using short homologies near the ends of the DNA fragments. This gene has a pseudogene on chromosome 3. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • CC: Coiled Coil
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K10865
    KEGG - Pathway(s):
    hsa03440; hsa03450
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    MRE11; DNA recombination and repair protein; Endo/exonuclease Mre11; HNGS1; ATLD; MRE11B; MRE11 homolog 1; Meiotic recombination 11 homolog A isoform 2; Meiotic recombination 11 homolog A isoform 1; MRE11 meiotic recombination 11 homolog A
    Approved Symbol:
    MRE11A
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 39
    Human (de-) phosphorylation sites: 39; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 1
    Human phosphorylation targets: 1; Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

  • Ataxia-telangiectasia-like disorder(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 02889 Entrez Gene ID: 4361 OMIM ID: 600814 Swissprot Accession: P49959; Q05D78;