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Description for Protein MPST

mercaptopyruvate sulfurtransferase
1 total interacting proteins;
Icon Book Platelet Evidence (proteome studies/others : 4/0)
(membrane: 1; platelet: 2; secretome: 1)
Summary:
This protein encoded by this gene catalyzes the transfer of a sulfur ion from 3-mercaptopyruvate to cyanide or other thiol compounds. It may be involved in cysteine degradation and cyanide detoxification. There is confusion in literature between this protein (mercaptopyruvate sulfurtransferase, MPST), which appears to be cytoplasmic, and thiosulfate sulfurtransferase (rhodanese, TST, GeneID:7263), which is a mitochondrial protein. Deficiency in MPST activity has been implicated in a rare inheritable disorder known as mercaptolactate-cysteine disulfiduria (MCDU). Alternatively spliced transcript variants encoding same or different isoforms have been identified for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • RHOD: Rhodanese Homology Domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.8.1.2
    KEGG - Orthology:
    K01011
    KEGG - Pathway(s):
    hsa00270; hsa01100
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    MST; TST2; MGC24539; 3-mercaptopyruvate sulfurtransferase; EC 2.8.1.2
    Approved Symbol:
    MPST
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 14
    Human (de-) phosphorylation sites: 14; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 4 : 0
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 11896 Entrez Gene ID: 4357 OMIM ID: 602496 Swissprot Accession: Q6FHN9; P25325;