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Description for Protein MOG

myelin oligodendrocyte glycoprotein
2 total interacting proteins; 1 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/1)
(platelet: 1)
Summary:
The product of this gene is a membrane protein expressed on the oligodendrocyte cell surface and the outermost surface of myelin sheaths. Due to this localization, it is a primary target antigen involved in immune-mediated demyelination. This protein may be involved in completion and maintenance of the myelin sheath and in cell-cell communication. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • TM: Transmembrane domain
  • IGV: Immunoglobulin V-Type
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    None Available
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    MGC26137; Myelin oligodendrocyte glycoprotein isoform beta5 precursor; Myelin oligodendrocyte glycoprotein isoform beta1 precursor; Myelin oligodendrocyte glycoprotein isoform beta3 precursor; Myelin oligodendrocyte glycoprotein isoform alpha3 precursor; Myelin oligodendrocyte glycoprotein isoform alpha2 precursor; Myelin oligodendrocyte glycoprotein isoform beta2 precursor; Myelin oligodendrocyte glycoprotein isoform beta4 precursor; Myelin oligodendrocyte glycoprotein isoform alpha4 precursor
    Approved Symbol:
    MOG
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 1
    Human (de-) phosphorylation sites: 1; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
    11831_10(0)
  • Isoform 9 : 0
  • Isoform 8 : 2
  • Isoform 7 : 2
  • Isoform 6 : 2
  • Isoform 3 : 2
  • Isoform 2 : 2
  • Isoform 1 : 3
    • Additional Identifiers:

    HPRD: 11831 Entrez Gene ID: 4340 OMIM ID: 159465 Swissprot Accession: Q5SUK9; Q5SUL1; Q16653;