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Description for Protein MMP12

matrix metallopeptidase 12 (macrophage elastase)
4 total interacting proteins; 2 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. It is thought that the protein encoded by this gene is cleaved at both ends to yield the active enzyme, but this processing has not been fully described. The enzyme degrades soluble and insoluble elastin. It may play a role in aneurysm formation and studies in mice suggest a role in the development of emphysema. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • ZnMc: Zinc-dependent metalloprotease
  • HX: Hemopexin-like repeats.
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    3.4.24.65
    KEGG - Orthology:
    K01413
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    Macrophage elastase; MME; Macrophage Metalloelastase
    Approved Symbol:
    MMP12
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • (1S,5S,7R)-N~7~-(BIPHENYL-4-YLMETHYL)-N~3~-HYDROXY-6,8-DIOXA-3-AZABICYCLO[3.2.1]OCTANE-3,7-DICARBOXAMIDE(db);
  • 2-[(4-fluorophenyl)sulfonylamino]-N-oxo-ethanamide(db);
  • 2-[2-(1,3-Dioxo-1,3-Dihydro-2h-Isoindol-2-Yl)Ethyl]-4-(4'-Ethoxy-1,1'-Biphenyl-4-Yl)-4-Oxobutanoic Acid(db);
  • Acetate Ion(db);
  • Acetohydroxamic Acid(db);
  • Batimastat(db);
  • CP-271485(db);
  • Marimastat(db);
  • N-(biphenyl-4-ylsulfonyl)-D-leucine(db);
  • N-(dibenzo[b,d]thiophen-3-ylsulfonyl)-L-valine(db);
  • N-HYDROXY-2(R)-[[(4-METHOXYPHENYL)SULFONYL](3-PICOLYL)AMINO]-3-METHYLBUTANAMIDE HYDROCHLORIDE(db);
  • N-ISOBUTYL-N-[4-METHOXYPHENYLSULFONYL]GLYCYL HYDROXAMIC ACID(db);
  • N-oxo-2-(phenylsulfonylamino)ethanamide(db);
  • N-oxo-2-[(4-phenylphenyl)sulfonylamino]ethanamide(db);
  • N-[(4-methoxyphenyl)sulfonyl]-D-alanine(db);
  • PF-00356231(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 03027 Entrez Gene ID: 4321 OMIM ID: 601046 Swissprot Accession: P39900;