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Description for Protein MMP2

matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)
37 total interacting proteins; 23 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 1/1)
(secretome: 1; undefined: 1)
Summary:
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes an enzyme which degrades type IV collagen, the major structural component of basement membranes. The enzyme plays a role in endometrial menstrual breakdown, regulation of vascularization and the inflammatory response. Mutations in this gene have been associated with Winchester syndrome and Nodulosis-Arthropathy-Osteolysis (NAO) syndrome. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • FN2: Fibronectin type 2 domain
  • HX: Hemopexin-like repeats.
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    3.4.24.24
    KEGG - Orthology:
    K01398
    KEGG - Pathway(s):
    hsa04670; hsa04912; hsa05200; hsa05219
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Collagenase type 4, 72 kD; Collagenase type 4A; Gelatinase, 72 kD; Gelatinase A; Gelatinase, neutrophil; CLG4; CLG4A; TBE-1
    Approved Symbol:
    MMP2
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 12
    Human (de-) phosphorylation sites: 12; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Captopril(db);
  • Marimastat(db);
  • SC-74020(db)

    Associated Genetic Diseases:

  • Multicentric osteolysis, nodulosis, and arthropathy(Pd);
  • Winchester syndrome(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 00386 Entrez Gene ID: 4313 OMIM ID: 120360 Swissprot Accession: P08253;