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Description for Protein MLLT4

myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
40 total interacting proteins; 23 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 1/0)
(platelet: 1)
Summary:
AF6 is a Ras (see HRAS; MIM 190020) target that regulates cell-cell adhesions downstream of Ras activation. It is fused with MLL (MIM 159555) in leukemias caused by t(6;11) translocations (Taya et al., 1998 [PubMed 9722616]).[supplied by OMIM] (PubMed Links)
Domains and Motifs:
  • PDZ: Domain present in PSD-95, Dlg, and ZO-1/2.
  • CC: Coiled Coil
  • RA: Ras association (RalGDS/AF-6) domain
  • FHA: Forkhead associated domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K05702
    KEGG - Pathway(s):
    hsa04520; hsa04530; hsa04670
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Myeloid/lymphoid or mixed-lineage leukemia translocated to 4 isoform 2; Myeloid/lymphoid or mixed-lineage leukemiatranslocated to 4 isoform 1; Myeloid/lymphoid or mixed-lineage leukemia translocated to 4 isoform 3; Afadin; Myeloid/lymphoid or mixed lineage leukemia, translocated to 4; Mixed lineage leukemia, translocated to 4; ALL1 fused gene from chromosome 6
    Approved Symbol:
    MLLT4
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 126
    Human (de-) phosphorylation sites: 126; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • (5R)-2-SULFANYL-5-[4-(TRIFLUOROMETHYL)BENZYL]-1,3-THIAZOL-4-ONE(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 01164 Entrez Gene ID: 4301 OMIM ID: 159559 Swissprot Accession: Q96C95; P55196; Q59FP0;