Search

Search for a specific protein in the Platelet Interactome


(Example: vasp)

 

Advanced Search

Get detailed protein information focusing on various characteristics and extract interaction networks

 

Legend

 

About

Go Back

Description for Protein ACHE

acetylcholinesterase
9 total interacting proteins; 2 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
Acetylcholinesterase hydrolyzes the neurotransmitter, acetylcholine at neuromuscular junctions and brain cholinergic synapses, and thus terminates signal transmission. It is also found on the red blood cell membranes, where it constitutes the Yt blood group antigen. Acetylcholinesterase exists in multiple molecular forms which possess similar catalytic properties, but differ in their oligomeric assembly and mode of cell attachment to the cell surface. It is encoded by the single ACHE gene, and the structural diversity in the gene products arises from alternative mRNA splicing, and post-translational associations of catalytic and structural subunits. The major form of acetylcholinesterase found in brain, muscle and other tissues is the hydrophilic species, which forms disulfide-linked oligomers with collagenous, or lipid-containing structural subunits. The other, alternatively spliced form, expressed primarily in the erythroid tissues, differs at the C-terminal end, and contains a cleavable hydrophobic peptide with a GPI-anchor site. It associates with the membranes through the phosphoinositide (PI) moieties added post-translationally. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    3.1.1.7
    KEGG - Orthology:
    K01049
    KEGG - Pathway(s):
    hsa00564
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    AChE-H; Acetylcholinesterase isoform E4-E6 precursor; YT; Acetylcholinesterase isoform E4-E5 precursor; AChE; Acetylcholine acetylhydrolase; EC 3.1.1.7; AcChoEase
    Approved Symbol:
    ACHE
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 1
    Human (de-) phosphorylation sites: 1; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • (1R)-1,2,2-TRIMETHYLPROPYL (S)-METHYLPHOSPHINATE(db);
  • (4ar,6s,8ar)-11-[8-(1,3-Dioxo-1,3-Dihydro-2h-Isoindol-2-Yl)Octyl]-6-Hydroxy-3-Methoxy-5,6,9,10-Tetrahydro-4ah-[1]Benzofuro[3a,3,2-Ef][2]Benzazepin-11-Ium(db);
  • (9S)-9-[(8-AMMONIOOCTYL)AMINO]-1,2,3,4,9,10-HEXAHYDROACRIDINIUM(db);
  • (R)-tacrine(10)-hupyridone(db);
  • (S)-tacrine(10)-hupyridone(db);
  • 1-(2-nitrophenyl)-2,2,2-trifluoroethyl]-arsenocholine(db);
  • 1-BENZYL-4-[(5,6-DIMETHOXY-1-INDANON-2-YL)METHYL]PIPERIDINE(db);
  • 1-Deoxy-1-Thio-Heptaethylene Glycol(db);
  • 1-ETHOXY-2-(2-ETHOXYETHOXY)ETHANE(db);
  • 1-[3-({[(4-AMINO-5-FLUORO-2-METHYLQUINOLIN-3-YL)METHYL]THIO}METHYL)PHENYL]-2,2,2-TRIFLUOROETHANE-1,1-DIOL(db);
  • 1S,3AS,8AS-TRIMETHYL-1-OXIDO-1,2,3,3A,8,8A-HEXAHYDROPYRROLO[2,3-B]INDOL-5-YL 2-ETHYLPHENYLCARBAMATE(db);
  • 2-(Acetylamino)-2-Deoxy-a-D-Glucopyranose(db);
  • 2-(N-Morpholino)-Ethanesulfonic Acid(db);
  • 2-[4-(DIMETHYLAMINO)PHENYL]-6-HYDROXY-3-METHYL-1,3-BENZOTHIAZOL-3-IUM(db);
  • 3,6,9,12,15-Pentaoxaheptadecane(db);
  • 3,7-BIS(DIMETHYLAMINO)PHENOTHIAZIN-5-IUM(db);
  • 3,8-Diamino-6-Phenyl-5-[6-[1-[2-[(1,2,3,4-Tetrahydro-9-Acridinyl)Amino]Ethyl]-1h-1,2,3-Triazol-4-Yl]Hexyl]-Phenanthridinium(db);
  • 3,8-Diamino-6-Phenyl-5-[6-[1-[2-[(1,2,3,4-Tetrahydro-9-Acridinyl)Amino]Ethyl]-1h-1,2,3-Triazol-5-Yl]Hexyl]-Phenanthridinium(db);
  • 3-Chloro-9-Ethyl-6,7,8,9,10,11-Hexahydro-7,11-Methanocycloocta[B]Quinolin-12-Amine(db);
  • 3-[(1s)-1-(Dimethylamino)Ethyl]Phenol(db);
  • Acetylcholine(db);
  • Ambenonium(db);
  • beta-L-fucose(db);
  • Choline(db);
  • Decamethonium(db);
  • Demecarium(db);
  • Donepezil(db);
  • Edrophonium(db);
  • Ephedrine(db);
  • Fucose(db);
  • Galantamine(db);
  • Gallamine Triethiodide(db);
  • Huperaine A(db);
  • Isoflurophate(db);
  • M-(N,N,N-Trimethylammonio)-2,2,2-Trifluoro-1,1-Dihydroxyethylbenzene(db);
  • Methyl Phosphinic Acid(db);
  • Methylphosphonic Acid Ester Group(db);
  • MF268(db);
  • Minaprine(db);
  • Monoisopropylphosphorylserine(db);
  • Neostigmine(db);
  • Physostigmine(db);
  • Pralidoxime(db);
  • Propidium(db);
  • Pyridostigmine(db);
  • Rivastigmine(db);
  • Tacrine(db);
  • TACRINE(8)-4-AMINOQUINOLINE(db);
  • Tetraethylene Glycol(db);
  • Tubocurarine(db)

    Associated Genetic Diseases:

  • YT blood group polymorphism(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 00010 Entrez Gene ID: 43 OMIM ID: 100740 Swissprot Accession: P22303;