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Description for Protein MAP3K11

mitogen-activated protein kinase kinase kinase 11
23 total interacting proteins; 10 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase contains a SH3 domain and a leucine zipper-basic motif. This kinase preferentially activates MAPK8/JNK kinase, and functions as a positive regulator of JNK signaling pathway. This kinase can directly phosphorylate, and activates IkappaB kinase alpha and beta, and is found to be involved in the transcription activity of NF-kappaB mediated by Rho family GTPases and CDC42. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • Tyr_Kinase: tyrosine kinase domain
  • CC: Coiled Coil
  • SH3: Src homology 3 domains
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.7.11.25
    KEGG - Orthology:
    K04419
    KEGG - Pathway(s):
    hsa04010
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Mitogen activated protein kinase kinase kinase 11; Mixed lineage protein kinase 3; PTK1; SPRK; MLK3
    Approved Symbol:
    MAP3K11
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 35
    Human (de-) phosphorylation sites: 35; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 3
    Human phosphorylation targets: 3; Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 02502 Entrez Gene ID: 4296 OMIM ID: 600050 Swissprot Accession: Q16584;