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Description for Protein MIF

macrophage migration inhibitory factor (glycosylation-inhibiting factor)
11 total interacting proteins; 8 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 1/0)
(platelet: 1)
Summary:
This gene encodes a lymphokine involved in cell-mediated immunity, immunoregulation, and inflammation. It plays a role in the regulation of macrophage function in host defense through the suppression of anti-inflammatory effects of glucocorticoids. This lymphokine and the JAB1 protein form a complex in the cytosol near the peripheral plasma membrane, which may indicate an additional role in integrin signaling pathways. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
5.3.2.1
KEGG - Orthology:
K07253
KEGG - Pathway(s):
hsa00350; hsa00360
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
Phenylpyruvate tautomerase; Glycosylation inhibiting factor; GIF; GLIF; MMIF
Approved Symbol:
MIF
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 1
Human (de-) phosphorylation sites: 1; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

None Available

Associated Genetic Diseases:

  • Rheumatoid arthritis, systemic juvenile, susceptibility to(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 01091 Entrez Gene ID: 4282 OMIM ID: 153620 Swissprot Accession: P14174;