Search

Search for a specific protein in the Platelet Interactome


(Example: vasp)

 

Advanced Search

Get detailed protein information focusing on various characteristics and extract interaction networks

 

Legend

 

About

Go Back

Description for Protein MICA

MHC class I polypeptide-related sequence A
2 total interacting proteins;
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
MICA encodes the higly polymorphic MHC (HLA) class I chain-related gene A. The protein product is expressed on the cell surface, although unlike canonical class I molecules does not seem to associate with beta-2-microglobulin. It is thought that MICA functions as a stress-induced antigen that is broadly recognized by intestinal epithelial gamma delta T cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • IGC: Immunoglobulin C-Type
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K07985
    KEGG - Pathway(s):
    hsa04650
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    MHC class I-like molecule PERB11.1-54.1; MHC class I-like molecule PERB11.1-62.1; PERB11.1 protein; HLA class I alpha chain; Alpha 1, 2, and 3 domains; Alternative name: PERB11.1; Stress inducible class I homolog; MHC class I-like molecule PERB11.1-7.1; MHC class I-like molecule PERB11.1-8.1; MHC class I-like molecule PERB11.1-13.1; MHC class I-like molecule PERB11.1-18.2; MHC class I-like molecule PERB11.1-35.1; MHC class I-like molecule PERB11.1-44.1; MHC class I-like molecule PERB11.1-44.3; MHC class I-like molecule PERB11.1-46.1; MHC class I-like molecule PERB11.1-47.1; MHC class I-like molecule PERB11.1-52.1
    Approved Symbol:

    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 1 : 1
    • Additional Identifiers:

    HPRD: 11853 Entrez Gene ID: 4276 OMIM ID: 600169 Swissprot Accession: Q29983; P30460;