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Description for Protein MGAT2

mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
No Interacting Proteins
Icon Book Platelet Evidence (proteome studies/others : 1/0)
(membrane: 1)
Summary:
The product of this gene is a Golgi enzyme catalyzing an essential step in the conversion of oligomannose to complex N-glycans. The enzyme has the typical glycosyltransferase domains: a short N-terminal cytoplasmic domain, a hydrophobic non-cleavable signal-anchor domain, and a C-terminal catalytic domain. Mutations in this gene may lead to carbohydrate-deficient glycoprotein syndrome, type II. The coding region of this gene is intronless. Transcript variants with a spliced 5' UTR may exist, but their biological validity has not been determined. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.4.1.143
    KEGG - Orthology:
    K00736
    KEGG - Pathway(s):
    hsa00510; hsa01100
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Alpha-1,6 mannosyl glycoprotein beta-1,2-n-acetylglucosaminyltransferase; GNT II; N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase II; Beta-1,2-N-acetylglucosaminyltransferase II; GnT2; UDP-N-acetylglucosamin,alpha-6-d-mannoside, beta-1,2-n-acetylglucosaminyltransferase II; CDGS2; GLCNACTII; EC 2.4.1.143; Mannoside acetylglucosaminyltransferase 2; GlcNAc-T II
    Approved Symbol:
    MGAT2
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

  • Carbohydrate-deficient glycoprotein syndrome, type II(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 1
  • Isoform 1 : 1
    • Additional Identifiers:

    HPRD: 04013 Entrez Gene ID: 4247 OMIM ID: 602616 Swissprot Accession: Q10469;