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Description for Protein MEP1B

meprin A, beta
14 total interacting proteins; 3 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
Meprins are multidomain zinc metalloproteases that are highly expressed in mammalian kidney and intestinal brush border membranes and in leukocytes and certain cancer cells. Mature meprins are oligomers of evolutionarily related, separately encoded alpha and/or beta subunits. Homooligomers of meprin-alpha (MEP1A; MIM 600388) are secreted; oligomers containing meprin-beta are associated with the plasma membrane. Substrates include bioactive peptides and extracellular matrix proteins. See MIM 600388 for further information on meprins.[supplied by OMIM] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • MAM: Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
  • MATH: meprin and TRAF homology
  • EGF: Epidermal growth factor-like domain.
  • TM: Transmembrane domain
  • ZnMc: Zinc-dependent metalloprotease
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    3.4.24.18
    KEGG - Orthology:
    K08606
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    Meprin A beta subunit; Endopeptidase 2; N-benzoyl-L-tyrosyl-P-amino-benzoic acid hydrolase beta subunit; PABA peptide hydrolase; Meprin A, beta
    Approved Symbol:
    MEP1B
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 1
    Human (de-) phosphorylation sites: 1; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 1 : 1
    • Additional Identifiers:

    HPRD: 02667 Entrez Gene ID: 4225 OMIM ID: 600389 Swissprot Accession: Q16820;