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Description for Protein MEN1

multiple endocrine neoplasia I
31 total interacting proteins; 8 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes menin, a putative tumor suppressor associated with a syndrome known as multiple endocrine neoplasia type 1. In vitro studies have shown menin is localized to the nucleus, possesses two functional nuclear localization signals, and inhibits transcriptional activation by JunD, however, the function of this protein is not known. Two messages have been detected on northern blots but the larger message has not been characterized. Alternative splicing results in multiple transcript variants. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • NLS: Nuclear localization signal
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    None Available
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    Menin isoform 1; Menin isoform 2; MEAI; SCG2
    Approved Symbol:
    MEN1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 12
    Human (de-) phosphorylation sites: 12; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

  • Adrenal adenoma, somatic(Pd);
  • Angiofibroma, somatic(Pd);
  • Carcinoid tumor of lung(Pd);
  • Hyperparathyroidism, familial isolated primary(Pd);
  • Lipoma, somatic(Pd);
  • Multiple endocrine neoplasia, type I(Pd);
  • Parathyroid adenoma, somatic(Pd);
  • Prolactinoma, hyperparathyroidism, carcinoid syndrome(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 7 : 0
  • Isoform 6 : 0
  • Isoform 5 : 0
  • Isoform 4 : 0
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 00564 Entrez Gene ID: 4221 OMIM ID: 131100 Swissprot Accession: Q9BUF0; O00255; Q9GZQ5;