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Description for Protein MAP3K3

mitogen-activated protein kinase kinase kinase 3
33 total interacting proteins; 23 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene product is a 626-amino acid polypeptide that is 96.5% identical to mouse Mekk3. Its catalytic domain is closely related to those of several other kinases, including mouse Mekk2, tobacco NPK, and yeast Ste11. Northern blot analysis revealed a 4.6-kb transcript that appears to be ubiquitously expressed. This protein directly regulates the stress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK) pathways by activating SEK and MEK1/2 respectively; it does not regulate the p38 pathway. In cotransfection assays, it enhanced transcription from a nuclear factor kappa-B (NFKB)-dependent reporter gene, consistent with a role in the SAPK pathway. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • S_T_kinase: Serine/Threonine protein kinases, catalytic domain
  • PB1: PB1 domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.7.11.25
    KEGG - Orthology:
    K04421
    KEGG - Pathway(s):
    hsa04010; hsa04722; hsa04912
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    MAP/ERK kinase kinase 3; MAPKKK3; MEKK3; EC 2.7.1.37; MEK kinase 3; Mitogen-activated protein kinase kinase kinase 3 isoform 1; Mitogen-activated protein kinase kinase kinase 3 isoform 2
    Approved Symbol:
    MAP3K3
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 66
    Human (de-) phosphorylation sites: 66; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 2
    Human phosphorylation targets: 2; Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 03965 Entrez Gene ID: 4215 OMIM ID: 602539 Swissprot Accession: Q99759;